Means and methods for inhibiting gene expression

Mittel und verfahren zur hemmung der genexpression

Moyens et procédés permettant d'inhiber l'expression génique


The present invention relates to a nucleic acid molecule encoding a polypeptide capable of binding to TFIIB and inhibiting gene expression, wherein the polypeptide (a) has the amino acid sequence of SEQ ID NO: 1; (b) is a fragment of the amino acid sequence of (a), said fragment lacking up to five amino acids at the C-terminus of the amino acid sequence of (a); or (c) has an amino acid sequence being at least 80% identical to the amino acid sequence of (a) or (b).




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