Procédés et compositions pour la prévention et le traitement de l'anémie

Methods and compositions for the prevention and treatment of anemia

Verfahren und Zusammensetzungen zur Prävention und Behandlung von Anämie

Abstract

Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematrocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.

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Patent Citations (10)

    Publication numberPublication dateAssigneeTitle
    EP-0640619-A1March 01, 1995Amgen Inc.Erythropoietin analogs with additional glycosylation sites
    US-4419446-ADecember 06, 1983The United States Of America As Represented By The Department Of Health And Human ServicesRecombinant DNA process utilizing a papilloma virus DNA as a vector
    US-4667016-AMay 19, 1987Kirin-Amgen, Inc.Erythropoietin purification
    US-4703008-AOctober 27, 1987Kiren-Amgen, Inc.DNA sequences encoding erythropoietin
    US-5739277-AApril 14, 1998Genentech Inc.Altered polypeptides with increased half-life
    WO-0024893-A2May 04, 2000Amgen Inc.Methodes et compositions permettant de prevenir et de traiter l'anemie
    WO-9105867-A1May 02, 1991Amgen Inc.Isoformes d'erythropoietine
    WO-9409257-A1April 28, 1994Kabushiki Kaisha Iseki Kaihatsu KokiShield excavator
    WO-9632478-A1October 17, 1996Genentech, Inc.Polypeptides modifies a demi-vie accrue
    WO-9734630-A1September 25, 1997Bio-Virus Research IncorporatedPeptide vaccine to prevent development of several herpes virus infections and/or atherosclerotic plaque

NO-Patent Citations (31)

    Title
    "Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fcy receptor", MOLEC. IMMUNOL., vol. 29, 1992, pages 633 - 639, XP000915240, DOI: doi:10.1016/0161-5890(92)90200-H
    "Remington's Pharmaceutical Sciences", 1980, MACK
    BROUDY ET AL., ARCH. BIOCHEM. BIOPHYS, vol. 265, 1988, pages 329
    CHENG, PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 5695
    COTES; BANGHAM, NATURE, vol. 191, 1961, pages 1065
    CUNNINGHAM ET AL., SCIENCE, vol. 244, 1989, pages 1081 - 1085
    CUNNINGHAM ET AL.: "High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis", SCIENCE, vol. 244, 2 June 1989 (1989-06-02), pages 1081 - 1085, XP000025308, DOI: doi:10.1126/science.2471267
    DELORME ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 9871 - 9876
    DUBE, J. BIOL. CHEM., vol. 263, 1988, pages 17516
    EGRIE ET AL.: "S7.7 The role of carbohydrate on the biological activity of erythropoietin", GLYCOCONJUGATE J., vol. 10, no. 4, 1993, pages 263, XP000906829, DOI: doi:10.1007/BF01209934
    EGRIE J C ET AL: "DEVELOPMENT AND CHARACTERIZATION OF NOVEL ERYTHROPOIESIS STIMULATING PROTEIN (NESP)", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, LONDON, GB, vol. 84, no. SUPPL. 01, 1 April 2001 (2001-04-01), pages 3 - 10, XP001059714, ISSN: 0007-0920, DOI: DOI:10.1054/BJOC.2001.1746
    EGRIE J C ET AL: "Novel erythropoiesis stimulating protein (NESP) has a longer serum half-life and greater in vivo biological activity than recombinant human erythropoietin (rHuEPO).", BLOOD, vol. 90, no. 10 SUPPL. 1 PART 1, 15 November 1997 (1997-11-15), 39th Annual Meeting of the American Society of Hematology;San Diego, California, USA; December 5-9, 1997, pages 56A - 57A, XP001059688, ISSN: 0006-4971
    EGRIE J C ET AL: "THE ROLE OF CARBOHYDRATE ON THE BIOLOGICAL ACTIVITY OF ERYTHROPOIETIN", GLYCOCONJUGATE JOURNAL, LUND, SE, vol. 10, 15 August 1993 (1993-08-15), pages 263, XP000906829, ISSN: 0282-0080
    EGRIE JOAN C ET AL: "Development and characterization of novel erythropoiesis stimulating protein (NESP).", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 16, no. Supplement 3, 2001, pages 3 - 13, XP001059695, ISSN: 0931-0509
    ELLIOTT ET AL., BLOOD, vol. 87, 1996, pages 2714
    ELLISON ET AL., NUCLEIC ACIDS RES., vol. 1Q, 1982, pages 4071 - 4079
    ESCHBACH ET AL.: "Correction of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin", NEW ENG. J. MED., vol. 316, no. 2, 8 January 1987 (1987-01-08), pages 73 - 78
    FIBI M R ET AL: "N- AND O-GLYCOSYLATION MUTEINS OF RECOMBINANT HUMAN ERYTHROPOIETIN SECRETED FROM BHK-21CELLS", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 85, no. 5, 1 March 1995 (1995-03-01), pages 1229 - 1236, XP002053700, ISSN: 0006-4971
    FISCHL ET AL.: "Recombinant Human Erythropoietin for Patients with AIDS Treated with Zidovudine", NEW ENG. J. MED., vol. 322, no. 21, 24 May 1990 (1990-05-24), pages 1488 - 1493
    GETHING ET AL., NATURE, vol. 293, 1981, pages 620 - 625
    HIGUCHI: "PCR Protocols", 1990, ACADEMIC PRESS, pages: 177 - 183
    KAUFMAN ET AL., MOL CELL. BIOL., vol. 5, 1985, pages 1750 - 1759
    KOMATSU ET AL., BLOOD, vol. 82, pages 456
    LAI ET AL., J. BIOL. CHEM., vol. 2LI, 1986, pages 3116
    LAUPACIS, LANCET, 1993, pages 1228 - 1232
    MACDOUGALL IAIN C ET AL: "Pharmacokinetics of novel erythropoiesis stimulating protein compared with Epoetin alfa in dialysis patients.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 10, no. 11, November 1999 (1999-11-01), pages 2392 - 2395, XP001059696, ISSN: 1046-6673
    MIYAKE ET AL., J. BIOL. CHEM., vol. 252, 1977, pages 5558
    SYED, NATURE, vol. 395, 1998, pages 511
    URLAB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 21, 1980, pages 4216 - 4220
    WELLS ET AL., GENE, vol. 34, 1985, pages 315 - 323
    ZOLLER ET AL., METH. ENZ., vol. 300, 1983, pages 468 - 500

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    Publication numberPublication dateAssigneeTitle